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Product Info Summary
| SKU: | A03087-1 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-Max-like protein X Mlx Antibody
SKU/Catalog Number
A03087-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Max-like protein X Mlx Antibody catalog # A03087-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Max-like protein X Mlx Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03087-1)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Mlx
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03087-1 is reactive to MLX in Human, Mouse, Rat
Applications
A03087-1 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
33.3kDa
Background of MLX
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
McGuinness B.E., PLoS Biol. 3:433-449(2005).
Kitajima T.S., Curr. Biol. 15:353-359(2005).
Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Validation Images & Assay Conditions
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Figure 1. Immunohistochemistry validation of MLX using Anti-Max-like protein X Mlx Antibody (A03087-1).
Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°CProtein Target Info & Infographic
Gene/Protein Information For MLX (Source: Uniprot.org, NCBI)
Gene Name
MLX
Full Name
Max-like protein X
Weight
33.3kDa
Alternative Names
BHLHD13; bHLHd13Max-like bHLHZip protein; BigMax alpha; BigMax protein; Class D basic helix-loop-helix protein 13; MAD7; MAX-like protein X; MLX; MXD7; TCFL4; TCFL4Protein BigMax; transcription factor-like 4; Transcription factor-like protein 4 MLX MAD7, MXD7, TCFL4, TF4, bHLHd13 MAX dimerization protein MLX max-like protein X|BigMax protein|MAX-like bHLHZIP protein|MLX, MAX dimerization protein|class D basic helix-loop-helix protein 13|transcription factor-like protein 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MLX, check out the MLX Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MLX: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Max-like protein X Mlx Antibody (A03087-1)
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No publications found for A03087-1
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